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692例脑梗死患者中合并IGT患者175例,将其随机分为药物干预组(88例)和对照组(87例),糖耐量正常(NGT)的脑梗死患者90例为NGT组。三组均予相同基础治疗(阿司匹林肠溶片,100mg/d),干预组另外加予二甲双胍(1000 mg/d)。结果脑梗死再发率较对照组明显降低。结论二甲双胍可以降低脑梗死合并IGT患者再发脑梗死的风险。
A total of 175 patients with IGT in 692 patients with cerebral infarction were randomly divided into medication intervention group (n = 88) and control group (n = 87). 90 patients with normal glucose tolerance (NGT) were classified as NGT group. All three groups were given the same basic treatment (aspirin enteric-coated tablets, 100mg / d), the intervention group was additionally given metformin (1000mg / d). Results The recurrent rate of cerebral infarction was significantly lower than that of the control group. Conclusion Metformin can reduce the risk of recurrent cerebral infarction in patients with cerebral infarction and IGT.