【摘 要】
：
以苯乙酮和苯胺衍生物为起始原料,通过缩合、环合、氯代反应,得到3种4-苯基-2-氯嘧啶衍生物,进而与苯基哌嗪盐酸盐反应,合成了12种带有不同取代基的2-哌嗪基-4-苯基嘧啶衍生
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以苯乙酮和苯胺衍生物为起始原料,通过缩合、环合、氯代反应,得到3种4-苯基-2-氯嘧啶衍生物,进而与苯基哌嗪盐酸盐反应,合成了12种带有不同取代基的2-哌嗪基-4-苯基嘧啶衍生物。该合成方法具有反应时间短、操作简便、副产物少的优点。各步产物均用MS,1H NMR,13C NMR表征。
Using acetophenone and aniline derivatives as starting materials, 3 kinds of 4-phenyl-2-chloropyrimidine derivatives were obtained by condensation, cyclization and chlorination reaction, and then reacted with phenylpiperazine hydrochloride to synthesize Twelve 12-piperazinyl-4-phenylpyrimidine derivatives with different substituents were obtained. The synthesis method has the advantages of short reaction time, simple operation and few by-products. The product of each step was characterized by MS, 1H NMR, 13C NMR.
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