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目的 研究血清透明质酸(HA)及Ⅳ型胶原蛋白 (CoIV)与矽肺病情之间的关系,探讨新的矽肺病病情监测方法。方法 用放免法测定 149例矽肺患者血清HA及CoIV含量,以同厂的 89例不接触矽尘工人作为对照。结果 Ⅲ期矽肺病人组血清HA水平为 272. 71±204. 65ng/ml,显著高于对照组 172. 31±120.18(P<0. 05); 148例矽肺患者血清CoIV平均浓度为 48. 94±277. 74ng/ml,与对照组相比有显著差异(P<0.001)。结论 血清HA、CoIV检测可作为矽肺患者病情监测的参考指标。
Objective To investigate the relationship between serum hyaluronic acid (HA) and type Ⅳ collagen (CoIV) and silicosis, and to explore new methods for monitoring the disease of silicosis. Methods The serum levels of HA and CoIV in 149 patients with silicosis were determined by radioimmunoassay, and 89 workers without exposure to silica dust were used as controls. Results The level of serum HA in patients with stage Ⅲ silicosis was 272. 71 ± 204. 65ng / ml, which was significantly higher than that in the control group (172. 31 ± 120.18, P <0.05). The mean level of CoIV in 148 patients with silicosis was 48. 94 ± 277. 74ng / ml, compared with the control group were significantly different (P <0.001). Conclusion Serum HA and CoIV can be used as reference indicators for the monitoring of patients with silicosis.