论文部分内容阅读
目的建立同时、快速测定化妆品中葵子麝香、佳乐麝香、二甲苯麝香、麝香酮、吐纳麝香和酮麝香6种人造麝香的气相色谱-质谱联用分析方法。方法以面霜、沐浴露、面膜等不同基质的化妆品为试样,选用乙酸乙酯进行提取,固相萃取(solid phase extraction,SPE)小柱净化,采用气相色谱-质谱联用外标法进行分析。结果葵子麝香、佳乐麝香、二甲苯麝香、麝香酮、吐纳麝香和酮麝香6种人造麝香在0.02~0.50μg/mL浓度范围内线性良好,相关系数为0.9968~0.9992。空白样品添加水平分别为0.20、0.40、2.00 mg/kg时,回收率在83.0%~110.38%之间,相对标准偏差在2.8%~7.5%之间,以上6种人造麝香的方法检出下限在20.0~40.0μg/kg之间。结论本方法简单、快速、准确,可满足化妆品中6种人造麝香的同时检测及确证需求。
OBJECTIVE To establish a method for simultaneous determination of 6 kinds of artificial musks of musk, musk, xylol, musk, musk, musk and musk in cosmetics by gas chromatography-mass spectrometry. Methods The cosmetics with different matrices such as cream, shower gel and facial mask were taken as samples. The samples were extracted with ethyl acetate and cleaned up by solid phase extraction (SPE) cartridge. The samples were analyzed by gas chromatography - mass spectrometry with external standard method . Results Six artificial musk of musk musk, musk musk, musk musk, musk ketone, tuina musk and musk ketone were linear in the range of 0.02-0.50 μg / mL with the correlation coefficient of 0.9968-0.9992. The recoveries were between 83.0% and 110.38% and the relative standard deviations were between 2.8% and 7.5% at the spiked levels of 0.20, 0.40 and 2.00 mg / kg, respectively. The lower limit of the above 6 artificial musk 20.0 ~ 40.0μg / kg. Conclusion The method is simple, rapid and accurate to meet the needs of simultaneous detection and confirmation of six kinds of artificial musk in cosmetics.