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目的:观察化瘀通脉注射液对大鼠主动脉球囊损伤后内皮素-1(ET-1)、一氧化氮(NO)、黏附分子-1(ICAM-1)的影响。方法:大鼠96只,随机分为3组:化瘀通脉组、丹参组和生理盐水组。各组采用球囊内膜剥脱法复制大鼠主动脉内膜增殖动物模型,每组自造模前1 d开始,分别静脉注射化瘀通脉注射液、丹参注射液和生理盐水,于造模后第5,10,15,25 d每组各随机选取8只大鼠取血,检测各组血浆ET-1、NOI、CAM-1含量。结果:ET-1浓度在各组随时间的变化均有升高,化瘀通脉组明显低于其余两组;化瘀通脉组NO含量明显高于其余两组;化瘀通脉组ICAM-1含量明显低于其余两组。结论:化瘀通脉注射液具有降低血浆ET-1I、CAM-1及提高血浆NO水平的作用,这可能是其抑制大鼠主动脉球囊损伤后内膜增殖的部分机制。
Objective: To observe the effect of Huayu Tongmai Injection on endothelin-1 (ET-1), nitric oxide (NO) and adhesion molecule-1 (ICAM-1) after balloon injury in rat aorta. Methods: Ninety-six rats were randomly divided into three groups: Huayu Tongmai group, Salvia miltiorrhiza group and saline group. In each group, rat aortic intimal hyperplasia models were created by balloon endarterectomy. From the 1st day before each model was established, intravenous injection of Huayu Tongmai injection, Salvia miltiorrhiza injection and physiological saline were performed. On the 5th, 10th, 15th and 25th days after each group, 8 rats were randomly selected to take blood. The levels of plasma ET-1, NOI, and CAM-1 were measured in each group. Results: The changes of ET-1 concentration in all groups increased with time. The Huayu Tongmai group was significantly lower than the other two groups; the NO content of Huayu Tongmai group was significantly higher than that of the other two groups; Huayu Tongmai group ICAM The content of -1 was significantly lower than the other two groups. Conclusion: Huatantongmai injection can reduce plasma ET-1I, CAM-1 and increase plasma NO level, which may be a part of its mechanism of inhibiting intimal hyperplasia after balloon injury of rat aorta.