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为了探讨P物质与慢性支气管炎发病的关系,采用放免法测定42例急性发作期和43例缓解期慢性支气管炎(慢支)病人血浆P物质含量,并与38例健康人作对照,同时测定急性发作组肺功能和动脉血气分析.结果表明,慢支急性发作组(1.299±0.606pmol/ml)及缓解组(0.635±0.149pmol/ml)血浆P物质均显著高于健康对照组(0.502±0.157pmol/ml),前两组间比较亦有非常显著性差异(P<0.01).并且慢支急性发作组P物质升高与肺功能FEV_1%和血气 PaO_2之间存在相关关系.提示P物质参与了慢支气道炎症的形成,可以做为判断病情轻重的一个非特异性指标.
In order to investigate the relationship between substance P and the pathogenesis of chronic bronchitis, the content of plasma substance P in 42 patients with acute exacerbation and 43 patients with chronic bronchitis (chronic bronchitis) were measured by radioimmunoassay and compared with 38 healthy controls Pulmonary function and arterial blood gas analysis of acute exacerbation group showed that plasma P level in acute exacerbation of chronic bronchitis group (1.299 ± 0.606 pmol / ml) and remission group (0.635 ± 0.149 pmol / ml) were significantly higher than those in healthy control group (0.502 ± 0.157pmol / ml). There was also a significant difference between the two groups (P <0.01), and there was a correlation between substance P elevation and pulmonary function FEV_1% and blood gas PaO_2 in acute episodes of chronic bronchitis, suggesting that substance P Participated in the formation of chronic bronchitis can be used as a non-specific indicators to determine the severity of illness.