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The bio pathological changes in the closed breeding Microtus fortis (as a laboratory animal) were observed. Forty six cases of Microtus fortis were divided into 3 different age groups, and investigated by the pathological technique combined with the electron microscopey. Results showed pathologic changes of closed breeding Microfus fortis were located mainly in liver and lung with close relation to aging. Eight types of pathological changes were found. There were breast carcinoma and cryptorechism in indivignal cases. The electron microscopic characteristics of the breast carcinoma were different from that of KM mouse. Therefore, for establishing a standardized laboratory animal, it is necessary to do pathological monitoring for Micritus fortis as a routine, and then in term of the results of which the germs may be screened.
The bio pathological changes in the closed breeding Microtus fortis (as a laboratory animal) were observed. Forty six cases of Microtus fortis were divided into 3 different age groups, and investigated by the pathological technique combined with the electron microscope. Closed breeding Microfus fortis were located mainly in liver and lung with close relation to aging. Eight types of pathological changes were found. There were breast carcinoma and cryptorechism in indivignal cases. The electron microscopic characteristics of the breast carcinoma were from from of KM mouse Thus, for establishing a standardized laboratory animal, it is necessary to do pathological monitoring for Micritus fortis as a routine, and then in term of the results of which the germs may be screened.