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目前有关维甲酸对免疫系统的作用知道很少, 新近的研究已提示其有免疫增强作用.几项电子显微研究结果提示芳香族维甲酸可刺激郎格罕细胞(LC),而LC被认为在表皮的免疫反应中起着关键的作用.因而,弄清楚维甲酸对表皮LC的数量和(或)功能是否有影响是很有意义的.为此,作者通过Ia抗原染色法和T细胞增殖试验分别检测口服芳香族维甲酸后对鼠表皮Ia~+LC的密度及向同种异体Ia反应性克隆T细胞系呈递Ia抗原作用的影响,并观察了表皮LC的形态和位置的改变.结果发现无论用大剂量或小剂量芳香族维甲酸处理,在最初几天表皮的LC密度增加,用大剂量对这种变化更加明显.之后趋向降低,2周后LC密度的降
At present, little is known about the effect of retinoic acid on the immune system, and recent studies have suggested that it has an immunopotentiating effect. Several electron microscopic studies suggest that aromatic retinoic acid stimulates Langerhans cells (LC), whereas LC is considered Plays a key role in the immune response of the epidermis.Therefore it is of interest to find out whether retinoic acid has an effect on the number and / or function of epidermal LC.To this end, the authors used Ia antigen staining and T cell proliferation The effects of oral araretic acid on the density of Ia ~ + LC in rat epidermis and the effect of Ia antigen presentation on allogeneic Ia-reactive T cell line were observed respectively, and the morphological changes of LC were observed. It was found that the EC density of the epidermis increased in the first few days, especially at high doses, after treatment with either high or low doses of ara-retinoids, followed by a trend toward reduced LC densities after 2 weeks