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目的分析研究胃肠间质瘤的临床诊断和外科治疗方法。方法回顾性分析2001年2月至2011年2月期间在我院经手术证实的36例胃肠道间质瘤患者的临床资料。结果 36例患者中临床症状表现为上腹部不适或疼痛15例,上消化道出血、黑便12例,腹部包块4例,体检发现5例。其中行胃楔形切除术16例,近端胃大部切除术7例,远端胃大部切除术10例,全胃切除3例。免疫组化结果,CD117阳性率为86.11%,CD34阳性率为80.56%。全组均行手术治疗,无手术死亡病例。结论胃间质瘤的诊断主要依靠术后病理切片及免疫组化,CD117是胃肠道间质瘤的特异性诊断指标,手术是治疗胃肠间质瘤的主要方法。
Objective To analyze the clinical diagnosis and surgical treatment of gastrointestinal stromal tumors. Methods The clinical data of 36 patients with gastrointestinal stromal tumors confirmed by surgery in our hospital from February 2001 to February 2011 were retrospectively analyzed. Results The clinical manifestations of 36 patients were upper abdominal discomfort or pain in 15 cases, upper gastrointestinal bleeding, black stool in 12 cases, abdominal mass in 4 cases and physical examination in 5 cases. Among them, 16 cases underwent gastric wedge resection, 7 cases underwent proximal gastrectomy, 10 cases underwent distal gastrectomy and 3 cases underwent total gastrectomy. Immunohistochemical results showed that the positive rate of CD117 was 86.11% and the positive rate of CD34 was 80.56%. All patients underwent surgical treatment, no surgical deaths. Conclusion The diagnosis of gastric stromal tumors mainly depends on the pathological sections and immunohistochemistry. CD117 is a specific diagnostic indicator of gastrointestinal stromal tumors. Surgery is the main method for the treatment of gastrointestinal stromal tumors.