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他汀类药物具有调脂以外的心血管保护作用,越来越多的实验和临床研究显示,他汀类药物的多效性很大程度上和其抑制小G蛋白的活性有关。现主要从他汀类药物影响小G蛋白信号通路方面,阐述其抑制心肌细胞肥大的主要机制。
Statins have cardiovascular protective effects other than lipid-lowering. More and more experimental and clinical studies have shown that the pleiotropic effect of statins is largely related to their ability to inhibit the activity of small G proteins. Now mainly from the statin drugs affect the small G protein signaling pathway, described its main mechanism of inhibition of myocardial cell hypertrophy.