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目的观察沸腾蒸馏水高浓度卡铂瘤内注射(PBHI)治疗中晚期小肝癌的疗效。方法将61例癌灶直径为0.5~6.0 cm的中晚期肝癌患者随机分为2组,治疗组(30例,52个癌结节)在超声引导下经皮经肝穿刺瘤内注射沸腾蒸馏水高浓度卡铂水溶液,对照组(31例,51个癌结节)瘤内注射无水乙醇,比较两组的临床疗效和毒副作用。结果在生活质量方面,2组比较差异无统计学意义(P>0.05);在瘤体大小变化、完全灭活率、6个月复发率、患者2年生存率方面,治疗组优于对照组(P<0.05)。两组均未出现明显的毒副作用。结论PBH I对小肝癌能够获得满意的局部治疗效果,无明显的毒副作用。
Objective To observe the effect of high concentration of carboplatin in boiling distilled water (PBHI) on small hepatocellular carcinoma in the advanced stage. Methods Sixty-one patients with advanced hepatocellular carcinoma of 0.5-6.0 cm in diameter were randomly divided into two groups. The treatment group (30 cases, 52 cancer nodules) under the guidance of ultrasound guided percutaneous transhepatic intratumoral injection of boiling distilled water The control group (31 cases, 51 cancer nodules) intratumoral injection of ethanol, the clinical efficacy and side effects of the two groups were compared. Results There was no significant difference in quality of life between the two groups (P> 0.05). The treatment group was superior to the control group in terms of tumor size change, complete inactivation rate, 6-month recurrence rate and 2-year survival rate (P <0.05). No obvious side effects occurred in both groups. Conclusion PBH I can achieve satisfactory local therapeutic effect on small hepatocellular carcinoma without obvious side effects.