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脑利钠肽(BNP)属循环内多肽激素之一。生理情况下,BNP主要由心室合成分泌,兼有利尿、排钠及扩血管等作用,类似于心房利钠因子(ANF)的综合效用。资料显示,患慢性心衰、AMI及高血压并左室肥厚时,循环内BNP升高。研究证实,监测血中ANF水平能预测心衰及AMI预后。然而关于BNP与心血管病预后间的关系尚未见报道。本文就老年人血浆BNP水平与远期死亡率的关系进行了分析。 541例受检老人,年龄≥85岁。其中充血性心衰 119例,兼有缺血性心脏病215例,合并高血压110例、或房颤62例,糖尿病、肾衰等非心血管疾病209例。研究中分别采备受试对象的空腹静脉血,用高敏免疫放射分析法测定血浆BNP浓度。嗣后人均随诊5年,观察分析血浆BNP水平与远期死亡率的关系。
Brain natriuretic peptide (BNP) is one of the circulating polypeptide hormones. Physiologically, BNP is mainly secreted by the ventricular synthesis, both diuretic, sodium and vasodilator effect, similar to atrial natriuretic factor (ANF) the combined effect. Data show that chronic heart failure, AMI and hypertension and left ventricular hypertrophy, circulating BNP increased. Studies confirm that monitoring the level of ANF in blood can predict the prognosis of heart failure and AMI. However, the relationship between BNP and the prognosis of cardiovascular disease has not been reported yet. This article analyzes the relationship between plasma BNP levels and long-term mortality in the elderly. 541 cases of elderly people, aged ≥ 85 years old. 119 cases of congestive heart failure, both ischemic heart disease in 215 cases, 110 cases of hypertension, or atrial fibrillation in 62 cases, diabetes, renal failure and other non-cardiovascular diseases in 209 cases. Fasting venous blood was collected from the subjects and plasma BNP concentrations were determined by high-sensitivity immunoradiometric assay. The average follow-up of 5 years later, observed and analyzed the relationship between plasma BNP levels and long-term mortality.