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目的:探讨乳腺癌合并妇科原发癌的临床病理特点、预后的关系。方法:对1991～2011年北京妇产医院23例乳腺癌合并妇科恶性肿瘤多原发癌的临床及病理资料进行回顾性分析。结果:乳腺癌合并子宫内膜癌11例,合并卵巢癌8例,合并宫颈癌3例,合并外阴癌1例,其中1例三重癌为双侧乳腺癌合并子宫内膜癌合并脑部恶性肿瘤。同期癌4例,异期癌19例。符合统计条件的病例中,3年生存率为100.0%,5年生存率为93.8%。结论:乳腺癌合并妇科恶性肿瘤与共同的雌孕激素受体、基因变异、放射线、抗癌药物的使用等因素有关,诊治及随访中必须警惕乳腺癌合并子宫、卵巢、宫颈等女性生殖器官多原发癌。
Objective: To investigate the clinicopathological features and prognosis of breast cancer complicated with primary gynecologic cancer. Methods: The clinical and pathological data of 23 cases of breast cancer complicated with primary cancer of gynecologic malignant tumor from 1991 to 2011 in Beijing Maternity Hospital were retrospectively analyzed. Results: 11 cases of breast cancer with endometrial carcinoma, 8 cases of combined ovarian cancer, 3 cases of cervical cancer combined with vulvar cancer in 1 case, of which 1 case of triple cancer as bilateral breast cancer with endometrial cancer combined with brain cancer . In the same period, 4 cases were cancerous and 19 cases were cancerous. According to the statistical conditions, the 3-year survival rate was 100.0% and the 5-year survival rate was 93.8%. Conclusions: There are many factors associated with breast cancer with gynecologic and gynecologic malignancies, such as common estrogen and progesterone receptors, gene mutation, radiation and the use of anticancer drugs. Multiple diagnosis and follow-up of breast cancer combined with multiple female genital organs such as uterus, ovary and cervix Primary cancer.