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目的:初步了解云南省昆明地区产检人群中的地中海贫血的检出情况。方法:采用法国Sebia公司Capillarys 2全自动毛细血管电泳仪及配套试剂,对在2009年8月～2010年8月期间进行产前检查者采静脉抗凝血2ml,进行血红蛋白电泳,筛查地中海贫血。结果:筛查2 077例孕妇中,检出β-地中海贫血39例,检出率为1.88%;α-地中海贫血39例,检出率1.88%;检出异常血红蛋白HbE 17例,检出率0.82%;检出Hb Constant Spring 7例,检出率0.33%;检出HbJ 1例,检出率0.048%。以上几组患者平均红细胞体积(MCV)、平均红细胞血红蛋白含量(MCH)不同程度减低。结论:云南省昆明地区血红蛋白病基因携带者并不少,因此开展产前诊断十分重要,这对杜绝重症地中海贫血儿童及减少地中海贫血儿童的出生,提高人口素质意义重大。
Objective: To understand the detection of thalassemia in the check-up population in Kunming, Yunnan Province. Methods: Capillarys 2 automatic capillary electrophoresis apparatus and matched reagents from Sebia Company of France were used to collect 2ml of anticoagulant blood of venous blood from August 2009 to August 2010 for hemoglobin electrophoresis and screening of thalassemia . Results: Of the 2 077 pregnant women screened, 39 cases of β-thalassemia were detected, the detection rate was 1.88%; α-thalassemia was detected in 39 cases, the detection rate was 1.88%; 17 cases of abnormal hemoglobin HbE were detected, the detection rate 0.82%; 7 cases of Hb Constant Spring were detected, the detection rate was 0.33%; 1 case of HbJ was detected, the detection rate was 0.048%. The above groups of patients with mean corpuscular volume (MCV), mean red blood cell hemoglobin content (MCH) decreased to varying degrees. Conclusion: There are not many carriers of hemoglobinopathies in Kunming, Yunnan Province. Therefore, it is very important to carry out prenatal diagnosis. It is of great significance to prevent the birth of children with thalassemia major and to reduce the birth of children with thalassemia and to improve the population quality.