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按比例杀菌试验证明,小白鼠喂以含0.1%乙硫异烟胺或丙硫异烟胺的食物45天,接种的麻风杆菌98.6%可被杀死,此比例仅逊于利福平。本文报告乙硫异烟胺-丙硫异烟胺间歇治疗和最低抑菌疗程试验的结果。本实验开始时用乙硫异烟胺,以后用丙硫异烟胺。材料与方法:采用作者实验室所分离的麻风杆菌株,每只小白鼠接种5×10~3菌量。感染后3周开始治疗。当乙硫异烟胺或丙硫异烟胺连续给药时,喂食浓度为0.1%。当每周1次、2次或3次以胃管给药时,每鼠0.25毫克。当未治疗的对照鼠菌量繁殖至每足垫5×10~5时,则剖杀药物治疗组鼠,检查
According to the proportion of bactericidal test showed that mice fed with 0.1% ethionamide or propylthiouracil food 45 days, vaccination of Leprosy 98.6% can be killed, this ratio is only inferior to rifampicin. This article reports the results of the ethionamide-propylthiouracil intermittent treatment and the minimum antibacterial treatment trial. The experiment started with ethionamide, later with propylthiourea. MATERIALS AND METHODS: Bacillus thuringiensis strains isolated from the authors laboratory were used. Each mouse was inoculated with 5 × 10-3 bacteria. Treatment started 3 weeks after infection. When ethionamide or prothioconosamine were administered continuously, the feeding concentration was 0.1%. When administered once, twice or three times a week as a gastric tube, 0.25 mg per mouse. When untreated control mice multiplied to 5 × 10 ~ 5 per foot pad, the rats in the drug-treated group were sacrificed and examined