近年来的研究发现,当脑组织在缺血、出血和外伤等情况下,脑内单胺类神经介质去甲肾上腺素(NE),多巴胺(DA)和5-羟色胺(5HT)等发生紊乱。1974年Wurtman等根据临床和实验资料提出了缺血后脑损伤的单胺类神经介质假说,认为单胺类神经介质在缺血性脑损伤的病理生理过程中起着 In recent years, the study found that brain tissue monoamine neurotransmitters such as norepinephrine (NE), dopamine (DA) and 5-hydroxytryptamine (5HT) were disturbed when they were in the condition of ischemia, bleeding and trauma. In 1974, Wurtman et al proposed the monoamine neurotransmitter hypothesis of ischemic brain injury based on clinical and experimental data, suggesting that monoamine neurotransmitters play a role in the pathophysiology of ischemic brain injury