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目的研究二极管发光器(LED)的多焦视网膜电图(mfERG)的一阶及二阶波形特点。设计前瞻性、非对照干预研究。研究对象18例(18眼)正常人。方法18眼随机分为两组分别作阴极射线管(CRT)及LED的mfERG检查。LED刺激时间分为1/10(1．7ms)、3/10(5ms)、5/10(8．3ms)、7/10(11．7ms)、10/10(16．7ms)5种。主要指标mfERG总和反应波形特点,P1、N1及N2波形态、振幅密度及潜伏期。结果CRT及LED刺激器mfERG一阶反应波形基本相似；CRT及LED刺激器的mfERG二阶反应波形不同,前者的P1波呈尖峰状,后者的P1波较宽,呈方形,且伴有一个较深的N2波。随着刺激时间的延长,LED刺激器的mfERG一阶及二阶反应中的P1波及N1波的振幅密度增加,潜伏期延长。结论CRT及LED刺激器的mfERG一阶反应波形基本相同,但LED的二阶反应波形更丰富,其可能包涵了更多视网膜内层信息。(眼科,2006,15：351-355)
Objective To study the first and second order waveform characteristics of multifocal electroretinogram (mfERG) of diode light emitting diode (LED). Design prospective, uncontrolled intervention study. 18 subjects (18 eyes) normal subjects. Methods 18 eyes were randomly divided into two groups for CRT and LED mfERG examination. LED stimulation time is divided into 1/10 (1.7ms), 3/10 (5ms), 5/10 (8.3ms), 7/10 (11.7ms), 10/10 (16.7ms) 5 kinds. The main indicators mfERG sum response waveform characteristics, P1, N1 and N2 wave morphology, amplitude density and latency. Results The mfERG first-order response waveforms of CRT and LED stimulator were basically similar. The mfERG second-order response waveforms of CRT and LED stimulator were different. The former P1 wave was spike-shaped, while the latter P1 wave was wide and square with one Deep N2 wave. With the extension of stimulation time, the amplitudes of P1 wave and N1 wave in the mfERG first-order and second-order reactions of LED stimulator were increased, and the incubation period was prolonged. Conclusion The mfERG first-order response waveforms of CRT and LED stimulator are basically the same. However, the second-order response waveforms of LED are more abundant, which may include more inner retina information. (Ophthalmology, 2006,15: 351-355)