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目的:探讨rt-PA静脉溶栓治疗在急性大脑中动脉脑梗死的临床疗效及安全性。方法:选取我院急性大脑中动脉脑梗死患者70例,随机分为实验组和对照组,每组35例。对照组给予保护神经、清除自由基及抗血小板抑制等治疗,实验组在对照组基础上联合阿替普酶静脉滴注。观察并比较治疗前后两组患者血清BNP,CRP及NSE水平的变化情况,以及临床疗效和并发症的发生率。结果:与治疗前相比,治疗后两组患者血清BNP,CRP及NSE水平均降低,差异具有统计学意义(P<0.05);与对照组比较,实验组患者治疗后血清BNP,CRP及NSE水平较低,差异具有统计学意义(P<0.05);实验组总有效率(85.71%)明显高于对照组(65.71%),差异具有统计学意义(P<0.05)。两组患者颅内出血、再灌注损伤、血管再闭塞等并发症的发生率比较,差异无统计学意义(P>0.05)。结论:rt-PA静脉溶栓治疗急性大脑中动脉脑梗死的临床疗效显著,能够降低患者血清BNP,CRP及NSE水平。
Objective: To investigate the clinical efficacy and safety of rt-PA intravenous thrombolysis in acute middle cerebral artery infarction. Methods: Seventy patients with acute middle cerebral artery infarction in our hospital were randomly divided into experimental group and control group, with 35 cases in each group. The control group was given protective neurons, free radical scavenging and antiplatelet therapy. The experimental group was treated with intravenous infusion of alteplase on the basis of the control group. The changes of serum BNP, CRP and NSE levels in both groups before and after treatment were observed and compared. The incidences of clinical efficacy and complications were also observed. Results: Compared with those before treatment, the levels of serum BNP, CRP and NSE decreased after treatment in both groups (P <0.05). Compared with the control group, serum BNP, CRP and NSE (P <0.05). The total effective rate (85.71%) in the experimental group was significantly higher than that in the control group (65.71%), the difference was statistically significant (P <0.05). The incidence of intracranial hemorrhage, reperfusion injury and vascular reocclusion in the two groups was no significant difference (P> 0.05). Conclusion: rt-PA intravenous thrombolytic therapy of acute cerebral infarction in the middle cerebral artery curative effect is significant, can reduce the serum BNP, CRP and NSE levels.