1引言诺氟沙星属于氨基喷淋衍生物，具有广谱抗菌作用，是临床上广泛应用的抗感染药物。健康人单剂量口服诺氟沙星后，24h尿中排出力叽一48％，其中用％左右的药物以原形排泄。服用剂量加倍时，则尿药浓度高达opndL，这一浓度超过尿路感染时大多数致病菌药敏值的好几倍。通常人 1 Introduction Norfloxacin belongs to amino spray derivatives, with broad-spectrum antibacterial effect, is widely used in clinical anti-infective drugs. After a single oral dose of norfloxacin in healthy people, urinary excretion of 24h jitter a 48%, of which about the use of drugs to excretion. Doubling dose, the urinary drug concentration up to opndL, the concentration of urinary tract infection than most of the susceptibility of several times. Common people