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目的：研究不同剂量羟考酮对腹部手术后的镇痛效果。方法将120例研究对象随机分为A、B、C、D 4组，每组30例，其中A、B、C组为实验组，D组为对照组。手术结束关腹时给予不同剂量的羟考酮以抑制手术后疼痛，A、B、C组分别给予0．05、0．10、0．15 mg／kg的剂量，D组只给予生理盐水5 ml。记录患者苏醒时间、清醒后的疼痛数字评分（NRS），嗜睡、恶心、呕吐、瘙痒等并发症的发生情况。结果 C组苏醒时间比D、A组延长，差异有统计学意义（P＜0．05）；A、B、C组与D组比较，NRS评分明显降低、镇痛时间均延长，差异有统计学意义（P＜0．05）；A组的镇痛持续时间明显短于B、C组，差异有统计学意义（P＜0．05）；B、C组的镇痛持续时间基本相似，差异无统计学意义（P＞0．05）。4组研究对象恶心、呕吐、嗜睡、瘙痒等并发症的发生率差异无统计学意义（P＞0．05）。结论0．10 mg／kg剂量的羟考酮用于腹部术后镇痛，取得良好的镇痛效果。“,”Objective To study on analgesic effect of different doses of oxycodone after abdominal operation. Methods 120 patients were randomly divided into A, B, C, D four groups, 30 patients in each group, group A, group B and group C as the experimental group, group D as control group. After surgical closure of abdomen, different doses of oxycodone were given to inhibit the pain after the operation. Group A, B, and C were given 0.05 mg/kg, 0.10 mg/kg, 0.15 mg/kg, respectively;group D as the control group, was given only saline 5 ml. The numbers of complications of the patients were recorded, such as the score of the pain after awake, the number of the pain after awake, the complications of sleepiness, nausea, vomiting and itching. Results The recovery time of group C was significantly longer than that of group D and group A (P0.05). Conclusion Given 0.10 mg/kg dose of oxycodone for postoperative analgesia can obtain good analgesic effect , and can effectively restrain the complications occurred.