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目的 :探讨血清胱抑素C(Cystatin C,CysC)与宫颈上皮内瘤变(cervical infraepithelial neoplasia,CIN)及早期宫颈癌的相关性,并评价其在宫颈癌早期诊断中可能的价值。方法:以本院100例CIN患者和103例早期宫颈癌患者作为实验组,同时收集本院150例健康体检者血清作为对照组;用全自动生化分析仪测定实验组及对照组血清CysC的浓度,并对各实验组与对照组的结果采用方差分析、t检验进行比较。结果:CIN组以及早期宫颈癌组中血清CysC的浓度明显高于对照组(P<0.01),而CIN组血清CysC的浓度与早期宫颈癌组相比无显著性差异(P=0.18);CysC的浓度在CIN不同阶段无显著性差异(P=0.12)。结论:CysC在CIN与早期宫颈癌患者血清中的表达明显高于对照组,与CIN病变程度无关,提示血清中CysC的检测在CIN患者和宫颈癌早期筛查中具有一定的临床价值。
Objective: To investigate the correlation between serum cystatin C (CysC) and cervical infraepithelial neoplasia (CIN) and early cervical cancer, and to evaluate its value in the early diagnosis of cervical cancer. Methods: One hundred patients with CIN in our hospital and 103 patients with early stage cervical cancer were selected as the experimental group, and the serum of 150 healthy people in our hospital was collected as the control group. The concentration of serum CysC in the experimental group and the control group was measured by automatic biochemical analyzer , And the results of each experimental group and control group were analyzed by ANOVA and t test. Results: The serum CysC level in CIN group and early cervical cancer group was significantly higher than that in control group (P <0.01), while the CysC level in CIN group was not significantly different from that in early stage cervical cancer group (P = 0.18) There was no significant difference in CIN at different stages (P = 0.12). Conclusions: The expression of CysC in serum of patients with CIN and early stage cervical cancer is significantly higher than that of control group, which has no correlation with the severity of CIN. It suggests that the detection of CysC in serum has some clinical value in CIN patients and cervical cancer early screening.