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近来p27基因与恶性肿瘤的关系引起了众多学者的关注。该基因编码的产物P27蛋白是一种细胞周期依赖性激酶的负性调控因子,参与细胞周期的调节。其表达下调与许多恶性肿瘤细胞的异常增殖关系密切。现对P27的生物学功能及其在乳腺肿瘤中的研究进展进行综述。1 P27的生物学功能1.1
Recently, the relationship between p27 gene and malignant tumors has attracted the attention of many scholars. P27 protein, a product of this gene, is a negative regulator of cell cycle-dependent kinase and is involved in the regulation of the cell cycle. Its down-regulation is closely related to the abnormal proliferation of many malignant tumor cells. Now the biological function of P27 and its research progress in breast tumors are reviewed. 1 P27 biological function 1.1