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探讨一氧化氮（ＮＯ）与ＴＩＡ发作的关系。测定２３例ＴＩＡ患者ＴＩＡ发作期和ＴＩＡ发作后第３ｄ血清中ＮＯ、超氧化物歧化酶（ＳＯＤ）和丙二醛（ＭＤＡ）含量。研究发现，ＴＩＡ发作时ＮＯ、ＳＯＤ含量显著降低（Ｐ＜０．０５），ＭＤＡ含量显著增高（Ｐ＜０．００１）；ＴＩＡ发作后第３ｄ，ＮＯ含量回升至正常水平（Ｐ＞０．０５），ＳＯＤ含量增加但仍低于正常（Ｐ＜０．００５），而ＭＤＡ含量持续高于正常（Ｐ＜０．００１）。结果表明，ＮＯ含量降低与ＴＩＡ发作有关，ＴＩＡ发作后缺血再灌注期ＮＯ可能参与组织损伤。本文提示，ＮＯ对ＴＩＡ有防治作用，ＳＯＤ能增强ＮＯ的治疗作用，ＴＩＡ发作后宜积极抗氧化治疗。
To investigate the relationship between nitric oxide (NO) and the onset of TIA. The levels of NO, SOD and MDA in TIA of 23 TIA patients at the onset of TIA and the 3rd day after TIA were measured. The levels of NO and SOD were significantly decreased (P <0.05) and the content of MDA was significantly increased (P <0.001) at TIA onset. The content of NO was increased to the normal level on the 3rd day after TIA onset (P> 0.05 ), SOD content increased but remained below normal (P <0.005), while MDA content continued to be higher than normal (P <0.001). The results showed that the decrease of NO content was related to the onset of TIA. NO during ischemia / reperfusion period after TIA onset may be involved in tissue injury. This article suggests that NO has a preventive and therapeutic effect on TIA, SOD can enhance the therapeutic effect of NO, TIA should be actively anti-oxidative therapy after the attack.