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以醋酸去氢表雄酮及表雄酮为原料,合成了ORF 9371的3位酮肟衍生物及17位羟基,5α双氢ORF 9371的酮肟衍生物共16个。经过SD大白鼠抗着床、抗旱孕筛选,发现5α双氢ORF9371的活性较其母体ORF 9371强1倍,酮肟衍生物的活性不增强。
A total of 16 ketone oxime derivatives of ORF 9371 and ketooxime derivatives of 17α hydroxyl group and 5α dihydro hydrogen ORF 9371 were synthesized from dehydroepiandrosterone acetate and epiandrosone. After SD rat anti-implantation, drought screening of pregnancy and found 5α double hydrogen ORF9371 activity than its parent ORF 9371 double, ketoxime derivatives activity is not enhanced.