二乙基二硫代氨基甲酸钠（ＤＤＴＣ）能明显抑制顺铂诱导鼠伤寒沙门氏菌ＴＡ１００，ＴＡ９８回变，有Ｓ９代谢活化系统时抑制作用增强，１６０．７４μｇ／ｐｌａｔｅＤＤＴＣ对０．２５～２．００μｇ／ｐｌａｔｅ顺铂抑制率为８７．４％～９５．７％（ＴＡ１００）和８９．４％～１０５．５％（ＴＡ９８）．小鼠ｉｐ顺铂１．５ｍｇ·ｋｇ－１，２４ｈ重复ｉｐ１次，每次给顺铂后１ｈｉｐＤＤＴＣ４００～８００ｍｇ·ｋｇ－１或同时ｉｇＤＤＴＣ７５０～１５００ｍｇ·ｋｇ－１．可显著降低顺铂诱发小鼠骨髓多染红细胞微核的形成．体内外实验结果表明ＤＤＴＣ可降低顺铂的致突变作用 Dicetyl dithiocarbamate (DDTC) significantly inhibited cisplatin-induced Salmonella typhimurium TA100, TA98 back-conversion, with S9 metabolic activation system inhibition increased, 160.74μg / plateDDTC 0.25 ~ 2.00μg / The cisplatin inhibition rates ranged from 87.4% to 95.7% (TA100) and from 89.4% to 105.5% (TA98). Mice ip ip cisplatin 1.5mg · kg-1,24h repeated ip1 times, each with cisplatin 1hipDDTC400 ~ 800mg · kg-1 or igDDTC750 ~ 1500mg · kg-1. Can significantly reduce cisplatin-induced mouse erythrocyte micronucleus micronucleus formation. In vitro and in vivo results show that DDTC can reduce cisplatin mutagenicity