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环磷酰胺、长春新硷、甲基苄肼对恶性黑色素瘤的疗效 本文叙述用环磷酰胺和长春新硷(CV)和CV加甲基苄肼(CVP)二组联合化疗治疗局限于皮肤或已扩散到皮下组织,肺,胸膜,肝脏,骨髂和脑的恶性黑色素瘤的经验。两组患者的平均年令,年令分布,男女比例的差异不大。 在CV组10例中,肿物全消1例,部分消退2例,有效率30％。在CVP组6例中,部分消退2例,有效率33％。CV与CVP两组的疗效差不多,且指出CV组在呕吐、白血球和血小板的减少,神经系统、脱发等付作用比CVP组小。作者认为,用CV联合化疗较长时间治疗恶性黑色素瘤是行之有效的。 Byrne MJ等:Cancer 38(5):1922,1976(英文) 王家录摘译 王德元校
Effects of Cyclophosphamide, Vincrisin, and Methyl Benzoquinone on Malignant Melanoma This article describes the use of cyclophosphamide and vinorelbine (CV) combined with CV plus procarbazine (CVP) in combination with chemotherapy for treatment of skin confined or The experience of malignant melanoma has spread to subcutaneous tissue, lung, pleura, liver, callus and brain. The average age, distribution of annual orders, and proportion of men and women in the two groups were not significantly different. In the CV group of 10 cases, the mass disappeared in 1 case, partially in 2 cases, and the effective rate was 30%. Among the 6 patients in the CVP group, 2 were partially resolved and the effective rate was 33%. The efficacy of CV and CVP was similar in both groups, and it was pointed out that the CV group had decreased vomiting, white blood cells and platelets, and the nervous system and hair loss were less than the CVP group. The authors believe that the use of CV combined with chemotherapy for a long time to treat malignant melanoma is effective. Byrne MJ et al.: Cancer 38(5): 1922, 1976 (English) Wang Jialu’s translation of Wang Deyuan’s school