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目的观察喜炎平注射液联合利巴韦林注射液治疗小儿手足口病的疗效。方法将150例小儿手足口病患儿按照随机数字法分为试验组和对照组,每组75例,试验组给予喜炎平注射液联合利巴韦林注射液治疗,对照组给予利巴韦林注射液治疗,比较2组治疗效果。结果试验组总有效率为97.33%高于对照组的85.33%,差异有统计学意义(P<0.05)。治疗前2组患儿肝功能损伤率及肌钙蛋白阳性率比较差异无统计学意义(P>0.05);治疗后2组肝功能损伤率及肌钙蛋白阳性率均降低,且试验组低于对照组,差异均有统计学意义(P<0.05)。试验组退热时间、疱疹消退时间、手足皮疹消退时间、康复时间均明显短于对照组,差异均有统计学意义(P<0.05)。2组均未出现明显不良反应。结论喜炎平联合利巴韦林治疗小儿手足口病效果较好,安全性高,可以推广使用。
Objective To observe the effect of Xiyanping injection combined with ribavirin injection in the treatment of hand-foot-mouth disease in children. Methods 150 children with HFMD were randomly divided into experimental group and control group according to random number method, each group had 75 cases. The experimental group was treated with Xiyanping injection combined with ribavirin injection and the control group with ribavirin Lin injection treatment, the treatment effect of two groups were compared. Results The total effective rate of the experimental group was 97.33% higher than that of the control group (85.33%), the difference was statistically significant (P <0.05). There was no significant difference in liver function damage rate and positive rate of troponin between the two groups before treatment (P> 0.05). The liver injury rate and troponin positive rate in the two groups after treatment were lower than those in the experimental group Control group, the difference was statistically significant (P <0.05). The test group antipyretic time, herpes subsided time, hand-foot rash subsided time, rehabilitation time were significantly shorter than the control group, the difference was statistically significant (P <0.05). No obvious adverse reactions occurred in both groups. Conclusion Xiyanping combined with ribavirin treatment of children with hand-foot-mouth disease is better, high safety, and can be widely used.