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目的:研究辛伐他汀对压力超负荷心肌肥厚大鼠心肌内源性抗氧化酶及血管紧张素转化酶活性的影响.方法:在左右肾动脉之间部分结扎腹主动脉诱导左心室肥厚(LVH).6周后,大鼠ig辛伐他汀1.8和3.6mg·kg~(-1)·d~(-1)8周,然后测定左心室组织内源性抗氧化酶和血管紧张素转化酶(ACE)活性以及脂质过氧化物(TBARS)含量.结果:LVH组(n=8)大鼠左心室组织血管紧张素Ⅱ(Ang Ⅱ)和TBARS含量、ACE及Cu,Zn-超氧化物歧化酶(SOD)活性分别比假手术组(n=7)大鼠增加163％、90％、130％和33％(P<0.01),而过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GSH-Px)的活性则分别比假手术组大鼠减少29％和23％(P<0.01).3.6mg·kg~(-1)·d~(-1)辛代他汀处理的大鼠(n=9)Ang Ⅱ、TBARS含量及ACE活性比LVH组大鼠分别减少30％,37％和51％,而CAT和GSH-Px的活性比LVH组大鼠分别增加32％和22％(P<0.01).辛伐他汀对SOD活性没有明显的影响.结论:心肌内抗氧化酶活性的变化与压力超负荷性心肌肥厚的形成和发展有关.辛伐他汀对大鼠心肌肥厚的抑制作用可能与其抗氧化作用有关.
Objective: To study the effect of simvastatin on endogenous myocardial antioxidant enzymes and angiotensin converting enzyme activity in myocardial hypertrophy of hypertensive rats.Methods: Left ventricular hypertrophy (LVH) was induced by ligating the abdominal aorta between the left and right renal arteries ). After 6 weeks, ig simvastatin was administered to rats at 1.8 and 3.6 mg · kg -1 · d -1 for 8 weeks, and then the levels of endogenous antioxidant enzymes and angiotensin converting enzyme (ACE) activity and lipid peroxidation (TBARS) .Results: The content of angiotensin Ⅱ (Ang Ⅱ) and TBARS, ACE and Cu, Zn-superoxide The activity of SOD was increased by 163%, 90%, 130% and 33% (P <0.01), while CAT and glutathione The activity of GSH-Px decreased by 29% and 23%, respectively (P <0.01) compared with the sham operation group, and the dose of 3.6 mg · kg -1 · d -1 (N = 9) decreased the content of Ang Ⅱ, TBARS and the activity of ACE in 30%, 37% and 51% of rats in LVH group, while the activity of CAT and GSH-Px increased 32% 22% (P <0.01) .Simvastatin had no significant effect on SOD activity.Conclusion: Intramyocardial The change of antioxidant enzyme activity is related with the formation and development of hypertensive cardiac hypertrophy.The inhibitory effect of simvastatin on cardiac hypertrophy may be related to its antioxidative effect.