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近年关于过敏治疗和相关的基础免疫学研究发展迅速,针对Ⅰ型超敏反应的研究措施有抗IgE治疗、合成肽免疫治疗、融合蛋白治疗、置换肽免疫治疗、DNA疫苗和免疫佐剂融合治疗等。过敏相关的免疫学研究进展包括变应原和FcγRI融合蛋白,可使抗原提呈细胞增加抗原表位呈现,诱导调节性T细胞的分化;一种幽门螺杆菌的毒性因子,可以刺激小鼠Th2反应性向Th1反应性的转化;特应性皮炎患者皮肤对金黄色葡萄球菌的易感增强,部分原因是对β-防御素的动员减弱;特应性体质者Th2反应性增强,导致了其Th1细胞的凋亡增加等。
In recent years, allergy treatment and related basic immunological research are developing rapidly. The research methods for type I hypersensitivity include anti-IgE therapy, synthetic peptide immunotherapy, fusion protein therapy, replacement peptide immunotherapy, DNA vaccine and immune adjuvant fusion therapy Wait. Advances in allergy-related immunology include allergens and FcγRI fusion proteins that increase the appearance of antigen-presenting cells and induce the differentiation of regulatory T cells; an H. pylori virulence factor that stimulates mouse Th2 Reactivity towards Th1 reactivity; skin susceptibility to Staphylococcus aureus in atopic dermatitis is partly due to weaker beta-defensin mobilization; increased Th2 reactivity in atopic constitution leads to its Th1 Increased cell apoptosis.