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目的探讨乌司他丁联合早期肠内营养对重症急性胰腺炎患者炎性反应因子水平的影响。方法将重症急性胰腺炎患者80例分为早期肠内营养组(CON组)和乌司他丁联合早期肠内营养组(UEN组)各40例。比较2组患者治疗前后血清hs-CRP、TNF-α、IL-6、IL-8和IL-10水平。结果 2组患者治疗前hs-CRP、TNF-α、IL-6、IL-8和IL-10水平比较差异均无统计学意义(P>0.05);治疗后2组患者血清hs-CRP、TNF-α、IL-6和IL-8均低于治疗前,IL-10高于治疗前,且UEN组变化幅度大于CON组,差异均有统计学意义(P<0.05)。结论乌司他丁联合早期肠内营养可显著改善重症急性胰腺炎患者全身炎性反应状态,疗效显著高于单纯早期肠内营养。
Objective To investigate the effect of ulinastatin combined with early enteral nutrition on inflammatory response in patients with severe acute pancreatitis. Methods Eighty patients with severe acute pancreatitis were divided into two groups: CON (enteral nutrition group) and Ulinastatin (enteral nutrition group) respectively. The levels of serum hs-CRP, TNF-α, IL-6, IL-8 and IL-10 in two groups before and after treatment were compared. Results There was no significant difference in the levels of hs-CRP, TNF-α, IL-6, IL-8 and IL-10 between the two groups before treatment (P> 0.05) The levels of IL-6, IL-6 and IL-8 were lower than those before treatment, IL-10 was higher than before treatment, and the changes in UEN group were greater than those in CON group (P <0.05). Conclusion Ulinastatin combined with early enteral nutrition can significantly improve the systemic inflammatory response in patients with severe acute pancreatitis, the effect was significantly higher than the simple early enteral nutrition.