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目的:Meta系统分析评价中国部分人群中Septin-9基因检测对结直肠癌的诊断价值。方法:检索万方、中国知网、维普、Pubmed、Embase数据库，发表日期从建库至2020年1月，筛选相关文献后提取数据，采用QUADAS-2标准对纳入文献进行质量评价，再对提取数据行初步合并，以判定阈值效应、异质性、诊断效能，进一步通过敏感性分析探讨异质性来源及亚组分析，最后评估是否存在发表偏倚。结果:共纳入17篇文献，包含病例组1 668例，对照组2 407例。合并灵敏度：0.74(95% n CI：0.72～0.76)，特异度：0.81(95% n CI：0.79～0.83)，阳性似然比：6.89(95% n CI：3.39～12.19)，阴性似然比：0.30(95% n CI：0.23～0.40)，诊断比值比：23.43(95% n CI：10.25～53.53)，SROC(Summary ROC)的曲线下面积(AUC)：0.821。亚组分析显示，Septin-9基因甲基化检测在结直肠癌的诊断中，组织样本和巢式甲基化特异PCR检测方法的诊断价值较高(DOR＝63.355、56.567)，而进行手术干预治疗后的诊断价值较低(DOR＝14.245)。n 结论:中国人群中Septin-9基因甲基化检测在结直肠癌的诊断价值较高，有望成为结直肠癌的诊断标记物。“,”Objective:Meta analysis was used to evaluate the diagnostic value of Septin-9 methylation in colorectal cancer.Methods:Research on the diagnostic value of Septin-9 methylation in WanFang, CNKI, Weip, Pubmed and Embase. The release time is from inception to January, 2020. After data extraction, QUADAS-2 standard was used to evaluate the quality of the included literature. Then the extracted data were preliminarily combined to determine the threshold effect, heterogeneity and diagnostic efficacy, and the source of heterogeneity and subgroup analysis were further discussed through sensitivity analysis. Finally, funnel plot was used to evaluate whether publication bias existed.Results:A total of 17 articles were included in the study, including 1 668 cases in the case group and 2 407 cases in the control group.The combined sensitivity: 0.74 (95% n CI: 0.72-0.76), specificity: 0.81 (95% n CI: 0.79-0.83), positive likelihood ratio: 6.89 (95% n CI: 3.39-12.19), negative likelihood ratio: 0.30 (95% n CI: 0.23-0.40), diagnostic ratio: 23.43 (95% n CI: 10.25-53.53), area under curve (AUC) of SROC (summary ROC): 0.821. Subgroup analysis showed that Septin-9 methylation detection was of high diagnostic value in the diagnosis of colorectal cancer by tissue samples and nested methylation specific PCR (DOR=63.355, 56.567), while the diagnostic value after surgical intervention is low (DOR=14.245).n Conclusions:The methylation detection of septin-9 gene in Chinese population is of high value in the diagnosis of colorectal cancer and is expected to become a diagnostic marker of colorectal cancer.