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评估善宁是否对肝缺血再灌注模型有保护作用。方法 :我们选用 30只成年SD大鼠随机分为 3且 ,组 1给予假手术 ,组 2首先将肝右叶给予 90min的热缺血 ,然后在恢复血流的同时进行肝中叶和肝左叶的切除 (大约切除 80 %肝组织 ) ,组 3与组 2的手术操作完全相同 ,但在剖腹术至术后 2 4h这段时间内用善宁(0 .5 μg/ 6h)皮下注射。而组 1,2都是用生理盐水处理大鼠。结果 :经善宁处理的大鼠的生存率由 0 (组 2 )提高至 6 0 % (组 3) (P <0 .0 5 ) ,而且血胆红素降低 (P <0 .0 5 )。结论 :善宁对肝细胞有保护作用。
To assess whether Shannon has a protective effect on the model of liver ischemia-reperfusion. Methods: Thirty adult SD rats were randomly divided into 3 groups. Group 1 was given sham operation. Group 2 was given warm ischemia for 90 min at right lobe of the liver, then middle and middle lobe of liver (About 80% of liver tissue was removed). The operation of group 3 was identical to that of group 2, but was subcutaneously injected with Shannon (0.5 μg / 6 h) during laparotomy to 24 hours after operation. Rats in group 1 and 2 were treated with saline. Results: The survival rate of rats treated with Sanning increased from 0 (group 2) to 60% (group 3) (P <0.05), and the serum bilirubin decreased (P0.05) . Conclusion: Shanning has a protective effect on hepatocytes.