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目的:探讨中孕期胎儿超声软指标对产前筛查21-三体综合征的价值。方法:2005年1月～2009年12月期间对在广西壮族自治区妇幼保健院行产前咨询和产前筛查的单胎妊娠孕妇(孕周18～24周)8 510例进行胎儿超声检测。对出现软指标孕妇按自愿原则抽取羊水进行核型分析。结果:8 510例胎儿中,发现超声软指标1 414例,检出率16.62%,其中羊水及脐血穿刺531例,占37.29%;检出21-三体综合征46例,检出率为0.54%。超声软指标诊断21-三体综合征敏感度为73.91%,特异度为83.27%,假阳性率为16.73%,总的超声软指标阳性似然比为4.62,阴性似然比为0.28。结论:中孕期胎儿超声软指标与21-三体综合征有关,单独存在的超声软指标发生21-三体综合征的几率较低,多项超声软指标提示21-三体综合征的风险明显增高。
Objective: To investigate the value of fetus ultrasound soft index in prenatal screening for prenatal screening of 21 trisomy. Methods: From January 2005 to December 2009, 8 510 singleton pregnant women (gestational weeks 18-24 weeks) with prenatal counseling and prenatal screening at Guangxi Maternal and Child Health Hospital were enrolled in this study. On the emergence of soft targets pregnant women according to the voluntary principle of amniotic fluid karyotype analysis. Results: Of the 8 510 fetuses, 1 414 soft-tissue ultrasound indexes were found, with a detection rate of 16.62%. Among them, 531 cases of amniotic fluid and umbilical cord punctures accounted for 37.29%; 46 cases of 21-trisomy syndrome were detected, the detection rate was 0.54%. The sensitivity, specificity and accuracy of ultrasonic soft-tip in diagnosing 21-trisomy syndrome were 73.91%, 83.27% and 16.73% respectively. The positive likelihood ratio of total soft-soft index was 4.62 and the negative likelihood ratio was 0.28. Conclusion: Fetal ultrasound soft index in the second trimester is related to 21 trisomy syndrome, the presence of ultrasound soft index 21-trisomy syndrome is low, a number of ultrasound soft-tip prompted 21 trisomy syndrome risk was significantly Increase.