目的:对比普鲁卡因与垂体后叶素单用和联用治疗中大量咯血的止血效果和不良反应。方法:患者分3组:普鲁卡因组,垂体后叶素组,两者联用组。结果:普鲁卡因组和垂体后叶素组止血效果无统计学差异(P>0.05),但垂体后叶素组不良反应显著高于普鲁卡因组(P<0.005);两者联用组止血效果优于普鲁卡因组和垂体后叶素组(P<0.05)。结论:普鲁卡因和垂体后叶素联用止血效果更强,不良反应更少。 Objective: To compare the hemostatic effects and side effects of massive procoagulant in the treatment of procaine and vasopressin alone and in combination. Methods: The patients were divided into 3 groups: procaine group, pituitrin group, the combination of the two groups. Results: There was no significant difference in the hemostatic effect between procaine and pituitrin (P> 0.05), but the adverse reactions of vasopressin were significantly higher than those of procaine (P <0.005) Hemostatic effect was better than procaine and pituitrin group (P <0.05). Conclusion: Combination of procaine and pituitrin hemostatic effect stronger, fewer adverse reactions.