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近年来,对于伤寒的研究已取得某些进展,现综述如下。伤寒的发病机理一、病原体的作用目前认为,伤寒杆菌的入侵门户是胃肠道,可能是小肠上段。对志愿者的研究表明,口服的伤寒杆菌可以在24小时内从粪便中被分离出,但通常在数天内便从粪便中消失。咽喉部曾一度被认为是开始入侵的部位,但这种可能性已被排除,因为志愿者雾化吸入伤寒杆菌之后并不发病。伤寒杆菌入侵小肠粘膜上皮的生化机理尚未明了,但其过程可能与细胞的吞噬作用相似,当伤寒杆菌靠近粘膜上皮时,上皮的纤毛便开始退变,为其
In recent years, some progress has been made in the research on typhoid fever, which are summarized as follows. The pathogenesis of typhoid fever First, the role of pathogens It is currently believed that the invasion of typhoid Salmonella gastrointestinal tract portal may be the upper small intestine. Studies on volunteers have shown that oral Salmonella typhi can be isolated from the stool within 24 hours, but usually disappear from the stool within days. The throat was once considered to be the site of invasion, but this possibility has been ruled out because volunteers did not develop morbidity after inhalation of Salmonella typhi. The biochemical mechanism of Salmonella typhi invasion of small intestinal mucosal epithelium is not yet clear, but the process may be similar to the phagocytosis of cells, when Salmonella typhi close to the mucosal epithelium, epithelial cilia began to degenerate, for its