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强直性脊柱炎(ankylosing spondylitis,AS)是一种以中轴关节受累为主的慢性炎症性关节疾病,其发病机制还不清楚。近几年,有学者相继提出关节源性肽学说、错误折叠假说等,这些前人已有综述。本文结合国外和我们前期的研究,提出肺炎衣原体抗原沉积致炎学说,并对Toll样受体(Toll-like receptors,TLRs)在AS发病中的作用进行简要综述。一、肺炎衣原体抗原致炎信号通路肺炎衣原体为单核细胞内寄生的病原体,其抗原具有广泛的、直接的免疫生物学效应,其中最突出的是致炎效应[1-5]。肺
Ankylosing spondylitis (AS) is a chronic inflammatory joint disease mainly involving the central axis joint. Its pathogenesis is still unclear. In recent years, some scholars have put forward the joint-source peptide theory, misfolding hypothesis, etc., these predecessors have been reviewed. In this paper, based on foreign and our previous studies, we propose the theory of antigenic deposition of Chlamydia pneumoniae, and briefly review the role of Toll-like receptors (TLRs) in the pathogenesis of AS. First, Chlamydia pneumoniae antigen-induced inflammatory pathways Chlamydia pneumoniae is a mononuclear intracellular parasitic pathogens, the antigen has a wide range of direct immunobiological effects, the most prominent of which is the pro-inflammatory effect [1-5]. lung