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目的了解泌尿生殖道支原体属的感染情况及其耐药性,为临床诊断、抗菌药物治疗提供可靠依据。方法采用法国生物梅里埃公司生产的试剂盒IST2进行支原体的培养、鉴定及药敏试验。结果 1262例患者中支原体属阳性546例,总的感染阳性率为43.26%;其中解脲脲支原体(Uu)单独感染阳性例数最多占首位(436例),Uu+人支原体(Mh)混合感染位列第2(92例),Mh单独感染阳性例数最少居末位第3(18例);Uu单独感染阳性率(79.85%)>Uu+Mh混合感染阳性率(16.85%)或(和)Mh单独感染阳性率(3.30%);药敏试验结果表明,Uu、Mh、和Uu+Mh混合感染对9种抗菌药物的敏感性各不相同,但对交沙霉素、多西环素、普那霉素均显示高度敏感,对环丙沙星、氧氟沙星都有较高的耐药性。结论泌尿生殖道支原体的感染以Uu单独感染为主,其次为Uu+Mh混合感染和Mh单独感染;治疗应根据培养、药敏试验结果结合药物的药代动力学,合理地选择抗菌药物或及时地调整使用的抗菌药物至关重要。
Objective To understand the infection and drug resistance of mycoplasma genitourinary tract and provide a reliable basis for clinical diagnosis and antimicrobial therapy. Methods The culture, identification and drug sensitivity test of mycoplasma were carried out with the kit IST2 produced by French bioMérieux. Results A total of 546 cases of Mycoplasma were positive in 1262 cases, with a total positive rate of 43.26%. Among them, the highest number of Uu infections was the highest (436 cases), and the Uu + Mycoplasma mixed infections The positive rate of Uu alone infection (79.85%)> Uu + Mh mixed infection positive rate (16.85%) or (and) Mh infection alone (3.30%); drug sensitivity test results showed that the mixed infection of Uu, Mh, and Uu + Mh sensitivity to 9 kinds of antimicrobial drugs vary, but josamycin, doxycycline, Both pristinamycin are highly sensitive and have high resistance to ciprofloxacin and ofloxacin. Conclusions UU infection is the most common infection in UU genital mycoplasma, followed by mixed infection with Uu + Mh and infection with Mh alone. The treatment should be based on the results of culture and drug sensitivity test in combination with the pharmacokinetics of the drug, and rational selection of antimicrobial agents or timely Adjust the use of antimicrobial drugs is essential.