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本文报道了5例头颈部鳞癌减影扫描检查的结果,并探讨了抗体成像技术的临床价值。头颈部鳞癌患者血清中癌胚抗原(carcinoembryonic antigen,CEA)通常是升高的,肿瘤细胞表面也有CEA,故而能用放射标记抗体检出。本组所用抗体是从肝转移结肠癌提纯的CEA免疫羊制备。在无菌条件下用标记抗体。去除游离的碘化物后,稀释、离心、滤过抗体。经过敏试验后,给患者静脉缓慢注射标记的抗体。在注射抗体前需连服碘化钾一周,以阻断甲状腺对放射性碘的摄取。注射抗体后24小时和48小时用连接电子计算机的γ射线照像机摄取颈、胸图像。
This article reports the results of subtraction scans of head and neck squamous cell carcinoma in 5 cases and discusses the clinical value of antibody imaging techniques. Carcinoembryonic antigen (CEA) in the serum of patients with head and neck squamous cell carcinoma is usually elevated, and CEA is also found on the surface of tumor cells, so it can be detected with radiolabeled antibodies. The antibodies used in this group were prepared from CEA immunized sheep purified from liver metastases. Labeled antibodies are used under sterile conditions. After removing free iodide, dilute, centrifuge, and filter the antibody. After susceptibility testing, patients were given a slow intravenous injection of labeled antibodies. It is necessary to take potassium iodide for a week before injecting antibodies to block the thyroid uptake of radioactive iodine. At 24 hours and 48 hours after the injection of the antibody, the neck and chest images were taken by a gamma ray camera connected to an electronic computer.