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目的分析丹参酮ⅡA磺酸钠注射液所致不良反应(ADR)的特点、规律及原因,寻找减少ADR发生的方法。方法检索国内万方数据(2000~2013年)、中国知网CNKI(2000~2013年)、国内期刊全文数据库维普(2000~2013年)中丹参酮ⅡA磺酸钠注射液所致ADR的文献并对其进行文献计量学分析。结果丹参酮ⅡA磺酸钠注射液所致ADR共46例,ADR主要发生在41~70岁之间;ADR主要发生在用药中;ADR累及多个器官和系统,主要是全身性反应、皮肤及附件反应。结论临床应了解丹参酮ⅡA磺酸钠注射液ADR的特点、规律及原因,严格把握丹参酮ⅡA磺酸钠注射液的适应证、用法用量,实行用药过程全程监护,以减少其ADR的发生。
Objective To analyze the characteristics, rules and causes of adverse reactions (ADR) induced by sodium tanshinone Ⅱ A sulfonate injection in order to find out ways to reduce the occurrence of ADR. Methods The literature about the ADR induced by tanshinone ⅡA sodium sulfonate injection in domestic Wanfang data (2000 ~ 2013), CNKI (2000 ~ 2013) and Vip (2000 ~ 2013) It conducts bibliometric analysis. Results Tanshinone Ⅱ A sodium sulfonate injection induced 46 cases of ADR, ADR occurred mainly in the 41 to 70 years old; ADR occurs mainly in the medication; ADR involving multiple organs and systems, mainly systemic reactions, skin and accessories reaction. Conclusions The clinical features, rules and causes of ADR in tanshinone Ⅱ A sodium sulfonate injection should be understood clinically. The indications and dosage of tanshinone Ⅱ A sodium sulfonate injection should be strictly controlled and the monitoring should be carried out throughout the course of drug use to reduce the occurrence of ADR.