Chondroitin sulfate proteoglycans(CSPGs)are key components of the extracellular matrix in the central nervous system(CNS).High levels of CSPGs are expressed in the embryonic mammalian CNS,where they play important roles in axon guidance and pathfinding.In the adult CNS,CSPGs are found in the perineu- Chondroitin sulfate proteoglycans (CSPGs) are key components of the extracellular matrix in the central nervous system (CNS). High levels of CSPGs are expressed in the embryonic mammalian CNS, where they play important roles in axon guidance and pathfinding. In the adult CNS, CSPGs are found in the perineu-