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目的评价小剂量奥美拉唑对上腹疼痛综合症型功能性消化不良(Epigastric pain syndrome-func-tional dyspepsia EPS-FD)患者的疗效。方法将96例EPS-FD患者随机分为奥美拉唑组48例及雷尼替丁组48例,前者给予奥美拉唑(洛赛克)10mg,每日早餐前服用;后者给予雷尼替丁150 mg,每日早餐前及晚上睡前服用。每周复查1次,由专科医生按预先设计统一表格观察记录,共治疗2周。比较2组的临床症状改善情况和不良反应发生情况。结果两组患者疗效比较,上腹痛或上腹烧灼感症状分级评分明显下降,治疗前后差异均有统计学意义(P<0.05~0.01);两组合并的餐后饱胀不适、早饱感症状的评分也有下降,但差异无统计学意义(P>0.05)。总有效率奥美拉唑组优于雷尼替丁组(P<0.05)。两组均未发现特别的不良反应。结论小剂量奥美拉唑对基于罗马Ⅲ标准定义下的EPS-FD的治疗安全有效,患者依从性好。
Objective To evaluate the efficacy of low-dose omeprazole in patients with epigastric pain syndrome-func- tional dyspepsia EPS-FD. Methods Ninety-six patients with EPS-FD were randomly divided into 48 patients in the omeprazole group and 48 patients in the ranitidine group. The former was given omeprazole (Losec) 10mg daily before breakfast. The latter was given Ray Nimidine 150 mg, daily before bed and at bedtime before breakfast. Review once a week, by the specialist pre-designed unified form of observation records, a total of 2 weeks of treatment. The clinical symptoms of two groups were compared and the incidence of adverse reactions was compared. Results The curative effect of upper abdominal pain or epigastric burning sensation was significantly decreased in both groups. The difference was statistically significant before and after treatment (P <0.05 ~ 0.01). The postprandial full discomfort, premature senility symptoms The score also decreased, but the difference was not statistically significant (P> 0.05). The total effective rate of omeprazole group was better than ranitidine group (P <0.05). No adverse reactions were found in either group. Conclusion Low-dose omeprazole is safe and effective for the treatment of EPS-FD based on the definition of Rome Ⅲ standard, and the patient compliance is good.