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抗霉素A(Antimycin A)是一类具有大环双内酯结构的天然产物,是典型的线粒体呼吸链细胞色素bc_1复合物Q_i位点抑制剂.鉴于该类化合物的独特结构与超高活性,越来越多的科研工作者对其展开了系统深入的研究.本文主要总结了Antimycin A的发现、生物活性研究,及近年来科研工作者对其进行结构改造所取得的成果.
Antimycin A is a kind of natural product with macrocyclic double lactone structure and is a typical Q_i inhibitor of mitochondrial respiratory chain cytochrome bc_1 complex.Due to its unique structure and high activity , More and more researchers carried out a systematic and in-depth study on it.In this paper, the findings of Antimycin A and its biological activity were summarized, and the achievements made by researchers in their structural transformation in recent years were summarized.