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Monofluoromethylation has attracted substantial attention in organic synthesis, owing to the increasing important applic......
Systematic review and Meta-analysis of efficacy and safety of dienogest in treatment of endometriosi
BACKGROUND The quality of life of women with endometriosis is substantially adversely affected by the pelvic pain caused......
Synthesis of Phenoxazinone Derivatives and Antiproliferative Activities on Wild-type and Drug-resist
A series of novel phenoxazinone derivatives (1-6) were designed and synthesized for evaluating their antitumor activitie......
The effect of non-alcoholic fatty liver disease on virologic response in patients with hepatitis B e
Objective To investigate the effect of non-alcoholic fatty liver disease(NAFLD)on virologic response in chronic hepatiti......
The ideal endpoint of hepatitis B virus(HBV)antiviral therapy is HBsAg loss,a difficult goal to obtain,especially in HBe......
Quantification of hepatitis B surface antigen(HBsAg)has been suggested to be helpful in the management of chronic hepati......
Treatment of chronic hepatitis B(CHB) has markedly improved in the last 15 years due to the availability of direct antiv......
Prediction of the ~(13)C NMR Chemical Shifts of 9,10-Dihydrophenanthrene Analogues by the GIAO Metho
After the geometry optimizations at the B3LYP/6-31+G(d,p) level, the NMR calculations of a series of 9,10-dihydrophenant......
Preparation of 4-and 6-desphenyl analogues of(-)-clausenamide and alternative synthesis of(+)-epi-cl
4- and 6-desphenyl analogues of(-)-clausenamide,6 and 7,were prepared in optical active form from commercially available......
Systematic structure modification of the side train of the lead compound saprothoquinone provides a series of salvicine ......
Synthesis and Insecticidal Activities of Novel Analogues of Chlorantraniliprole Containing Nitro Gro
Twelve novel analogues of chlorantraniliprole containing nitro group were synthesized,and their structures were characte......
Metalla-aromatics are analogues of conventional organic aromatic molecules in which one of the CH groups is formally rep......
Boron- and silicon-bridged bis(diphenylphosphino)-type ligands for chromium-catalyzed ethylene oligo
PNP-type ligands showed very good property in the catalytic systems of PNP/Cr(Ⅲ)/methylaluminoxane(MAO)for ethylene sel......
A series of poly(aryleneethynylene)s containing dibenzosilole unit has been synthesized by palladium-catalyzed Sonogashi......
Solamargine,(25R)-3-{O-L-rhamnopyranosyl-(1 2)-[O-L-rhamnopyranosyl-(1 4)]-D-glucopyranosyloxy}-22-Nspirosol-5-ene,isola......
Design,synthesis and biological evaluation of new rhodacyanine analogues as potential antitumor agen
In an attempt to develop potent antitumor agents,new rhodacyanine analogues containing the pyridinium ring(5a-5h),the is......
Metsulfuron-methyl molecularly imprinted polymer(MIP)-coated stir bar was prepared for sorptive extraction of sulfonylur......
To study structure-activity relationship of rhodomyrtone against Gram-positive bacteria,structural modification of rhodo......
[Objective] To synthesize chalcone analogues and study their antifungal activity so as to find high-efficient and safe c......
Thirteen thiomorpholine-bearing compounds were designed and synthesized as dipeptidyl peptidase IV(DPP-IV) inhibitors, w......
In order to find novel antibacterial agents with superior antibacterial activity and overcoming multidrug resistance,a s......
为进一步探讨ADPR的生物学功能,本文设计并合成了用天门冬氨酸二肽代替焦磷酸结构的一类新型ADPR类似物。通过以5’-氨基腺苷或其......
Two monocarbonyl analogs of curcumin containing bis(2,6-difluorobenzyl) were synthesized,and their molecular structures ......
Synthesis and Crystal Structure of N-((6-chloropyridin-3-yl)methyl)-6-ethoxy-N-ethyl-3-nitropyridin-
The title compound N-((6-chloropyridin-3-yl)methyl)-6-ethoxy-N-ethyl-3-nitropyri-din-2-amine(4) was synthesized by react......
Phenylene-gallosilicates were prepared with the same crystalline structure as their aluminum analogues. The new Ga-Eni C......
Enantioselective synthesis of(1S,4R)-N-(benzylcarbamoyl)-4-aminocyclopent-2-en-1-ol by Candida antar
An efficient biocatalytic process has been developed to obtain optically pure(1S,4R)-N-(benzylcarbamoyl)-4-aminocyclopen......
Ru(Ⅱ)-catalyzed ortho-amidation and decarboxylation of aromatic acids: a versatile route to meta-sub
Carboxylate as a promising and valuable directing group has attracted a great deal of attention.However,employing it as ......
AIM: To analyze the clinical features and risk factors of adverse reactions associated with telbivudine. METHODS: Clinic......
In search of novel anticancer agents,a series of thalidomide analogs(6a-j)were designed and synthesized.Cytotoxicity of ......
Up to date, there are two types of drugs approved to treat hepatitis B: interferons and nucleos (t) ide analogues. Howev......
Five novel curcumin analogues bearing different substituents at 4-position of phenyl group were synthesized.Their struct......
2-(2-Phenylethyl)chromones from Endophytic Fungal Strain Botryosphaeria rhodina A13 from Aquilaria s
Objective To study the characteristic 2-(2-phenylethyl)chromone components of endophytic fungal strain of Aquilaria sine......
A new type of dendritic polymer, named dendronized hyperbranched polymer (DHP), was prepared successfully by the macro-m......
Tuning the solid-state emission of the analogous GFP chromophore by varying alkyl chains in the imid
New analogues of green fluorescent protein(GFP)chromophore mGFP-Cn(n=1,3,5,11)with alkyl chains of different lengths in ......
Simplified aminocoumarin analogues as anticancer agents:Amino isosteric replacement in the noviose m
Simplified aminocoumarin analogues,either noviosylated or simple basic heterocycle attached 3-amido-coumarin compounds,a......
Linear diribonucleoside phosphotriester is an important intermediate for synthesizing biologically important compounds,s......
Design, synthesis, insecticidal evaluation and molecular docking studies of cis-nitenpyram analogues
Based on the strategies of receptor structure-guided neonicotinoid design, a series of novel cis-nitenpyram analogues be......
A catalyst- and solvent-free multicomponent synthesis of 7-azagramine analogues via a Mannich type r
A catalyst- and solvent-free protocol for the synthesis of 7-azagramine analogues is described via a three-component Man......
Conjugated microporous polymers with distinctive π-electronic properties exhibiting enhanced optical
The short review discusses a family of amorphous porous organic polymers,conjugated microporous polymer(CMP),which is di......
3D-QSAR and docking studies on 2-arylbenzoxazole and linker-Y transthyretin amyloidogenesis inhibito
Transthyretin(TTR),a plasma protein with a tetramer structure,could form amyloid fibril associated with several human di......
从纤维堆囊菌菌株So0157-2发酵吸附树脂的提取物中分离得到四个天然埃博霉素衍生物,包括两个14元环埃博霉素L(1)和L1(2),以及两个......
Three pairs of novel 2-aryl-3,4,5-trihydroxypiperidines(6–8 and their enantiomers),the piperidine analogues of the pyrr......
An efficient approach has been developed for the synthesis of 5,5’-diaryl-2,2’-bipyridines via their 1,2,4-triazine an......
Two fluorescence “turn-on” Zn~(2+) probes were developed by introducing an anthracenyl fluorophore through the linkage......
The thiazoylmethoxy modification on pyrazole oximes: Synthesis and insecticidal biological evaluatio
A series of new pyrazole oximes bearing substituted thiazole ring were designed and prepared. The structures of the titl......
Synthesis of C8-alkyl-substituted purine analogues by direct alkylation of 8-H purines with tetrahyd
C8-Alkyl-substituted purine analogues were synthesized through direct alkylation of 8-H purine with tetrahydrofuran in t......
Synthesis,Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trim
Many small-molecule compounds have been evaluated with potential antiproliferative activities. Ethyl 1-(phenylcarbamoyl)......
抗霉素A(Antimycin A)是一类具有大环双内酯结构的天然产物,是典型的线粒体呼吸链细胞色素bc_1复合物Q_i位点抑制剂.鉴于该类化合......
Searching for more safe and effective agents for HIV treatments is still an urgent topic worldwide.Based on our continuo......
We describe in this work an alkyne-hydrosilylation approach to synthesize a series of novel polysiloxane sidechain LCPs ......
