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水楊酸鈉能使正常大鼠腎上腺内抗坏血酸和胆固醇含量及血液中嗜伊紅白血球明显減少;使正常豚鼠、大鼠和犬血浆17-羟皮貭固醇类激素浓度升高,尿中固醇类激素含量增加。但在切除垂体或腎上腺动物或以戊巴比妥鈉或Dial麻醉动物,水楊酸鈉的上述各种作用均不出現。血浆17-羟皮貭固醇类激素含量升高与水楊酸鈉的抗风湿症作用間有定性关系,但非定量关系。大剂量水楊酸鈉可使正常人血液嗜伊紅白血球减少,血浆17-羟皮貭固醇类激素及尿中固醇类激素含量明显增加,但治疗剂量則无此作用。风湿病人服用治疗或中毒剂量水楊酸鈉时,血浆或尿中17-羟皮貭固醇类激素含量均不增加。水楊酸鈉对垂体——腎上腺系統及其分泌物可能有双重影响:(一)兴奋垂体——腎上腺系統。(二)使血液中皮貭激素的轉移率加快,但并不增加固醇类激素从尿中排出。至于水楊酸鈉的抗风湿作用是否系通过垂体——腎上腺系統,目前仍在爭論中。
Sodium salicylate can make normal adrenal ascorbate and cholesterol content and blood eosinophil significantly reduced; the normal guinea pigs, rats and dogs plasma 17-hydroxysteroid steroid hormone concentration, urinary solid Alcohol hormone content increased. However, the above effects of sodium salicylate do not appear in the excision of pituitary or adrenal animals or animals anesthetized with sodium pentobarbital or Dial. Plasma 17-hydroxysteroid steroid hormone levels and sodium salicylate anti-rheumatoid role between the qualitative relationship, but non-quantitative relationship. High doses of sodium salicylate can reduce blood eosinophilic white blood cells in normal people, plasma 17-hydroxysteroid steroid hormones and urinary steroid hormone levels increased significantly, but no effect of treatment dose. Rheumatoid patients taking therapeutic or toxic doses of sodium salicylate, plasma or urine 17-hydroxysteroid steroid hormone levels did not increase. Sodium salicylate may have a dual effect on the pituitary-adrenal system and its secretions: (i) Excitement of the pituitary-adrenal system. (B) to speed up the transfer of blood in the dermatocaridin, but does not increase the steroid hormone excreted from the urine. Whether the anti-rheumatoid effect of sodium salicylate crosses the pituitary-adrenal system is still under debate.