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目的探讨血浆载脂蛋白(apolipoprotein,apo)AⅠ和E水平在维吾尔族妇女子宫颈病变进程中的变化及其意义,验证其作为子宫颈癌及癌前病变共性候选血浆标志物的特异性和敏感度。方法收集维吾尔族妇女慢性子宫颈炎、鳞状上皮内高度病变(high grade squamous intraepithelial lesion,HSIL)、子宫颈鳞癌(cervical squamouscell carcinoma,CSCC)的早期(Ⅰ～ⅡA)和晚期(ⅡB～Ⅳ)患者血浆标本82例,采用ELISA检测血浆apoAⅠ和apoE水平。结果随着子宫颈病变病理进展,血浆apoAⅠ和apoE含量发生梯度性变化,其组间差异有统计学意义(P<0.05)。与子宫颈炎组比较,CSCC早期和晚期两组血浆apoAⅠ水平显著下降(P<0.01),而HSIL组血浆apoAⅠ水平变化无统计学意义(P>0.05)。HSIL、CSCC早期和晚期组患者之间血浆apoE水平差异不明显,但3组患者与子宫颈炎组比较,该蛋白含量上升明显,其差异有统计学意义(P<0.05)。结论血浆apoAⅠ和apoE变化与子宫颈病变病理进程关系密切,可以成为子宫颈癌特异性早期预警指标。
Objective To investigate the changes of plasma apolipoprotein A (Ⅰ) and apolipoprotein E (apo) levels and their significance in Uygur women with cervical lesions and to verify their specificity and sensitivity as common plasma markers of cervical cancer and precancerous lesions degree. Methods Uyghur women with chronic cervicitis, high grade squamous intraepithelial lesion (HSIL), early stage (Ⅰ ~ ⅡA) and late stage (ⅡB ~ Ⅳ) of cervical squamous cell carcinoma (CSCC) Plasma samples of 82 patients were used to detect plasma apoA Ⅰ and apoE levels. Results With the pathological progress of cervical lesions, the plasma levels of apoA Ⅰ and apoE had a gradient change, the difference between the groups was statistically significant (P <0.05). Compared with the cervicitis group, plasma apoAI level was significantly decreased in the early and late CSCC groups (P <0.01), while there was no significant difference in the apoA Ⅰ level in the HSIL group (P> 0.05). There was no significant difference in the level of plasma apoE between HSIL and CSCC patients. However, the protein levels of HSIL and CSCC patients in cervicitis group were significantly increased (P <0.05). Conclusion The changes of plasma apoA Ⅰ and apoE are closely related to the pathological process of cervical lesions and may become the specific early warning indicator of cervical cancer.