论文部分内容阅读
蕈样肉芽肿是具有特殊临床症状及组织病理学改变的一种T细胞性淋巴瘤,而Sézary综合征则为蕈样肉芽肿的一种白血病型表现。本文在于研究蕈样肉芽肿及Sézary综合征病例是否有异常量的血清胸腺因子。血清胸腺因子为一种具有生物学活性的肽,它存在于包括人类在内的各种动物的血清中,由Bach等从猪血清中分离并作了定性等研究。它的量决定于胸腺的功能,在婴儿体内含量最高,以后随着年龄增长而渐下降,至40岁以后降至极少量。作者所用的生物测定法是根据这样的一个观察,即被切除胸腺的成年鼠脾细胞本来对硫唑嘌呤比正常脾细胞更有抵抗性,在血清胸腺因子的影响下却变得对硫唑嘌呤敏感起来。这种敏感性是通过玫瑰花瓣形成细胞受到抑制而测出的。作者对23
Mycosis fungoides is a T-cell lymphoma with special clinical and histopathological changes, and Sézary’s syndrome is a leukemic manifestation of mycosis fungoides. This article examines whether mycosis fungoides and Sézary syndrome have abnormal amounts of serum thymic factor. Serum thymidine is a biologically active peptide, which exists in the serum of various animals, including humans, was isolated from porcine serum by Bach et al and qualitatively studied. Its amount depends on the function of the thymus, the highest content in the baby, then gradually decline with age, to a very small amount after 40 years of age. The bioassay used by the authors was based on the observation that adult murine spleen cells resected from the thymus were inherently more resistant to azathioprine than normal splenocytes but became susceptible to azathioprine under the influence of serum thymic factor Sensitive. This sensitivity is measured by inhibition of rose petal-forming cells. The author of 23