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目的：探讨微粒子活性炭（ＣＨ４０）在口腔鳞癌颈淋巴清扫术中的指导作用。方法：术前对２２例口腔鳞癌患者肿瘤内或肿瘤周围注入微粒子活性炭（ＣＨ４０）混悬液，术中根据淋巴结黑染情况作为标记来指导颈淋巴清扫术。结果：术中可见颈淋巴结有广泛不同程度的黑染，甚至包埋在脂肪组织内的直径１ｍｍ大小的淋巴结；注炭组黑染及未黑染的淋巴结转移比率无显著差异；注炭组平均每侧颈部清除４２．５个淋巴结，明显高于对照组的平均２６．２个淋巴结（Ｐ＜０．０１）；注炭组根治性颈清扫与功能性颈清扫清除的淋巴结数无明显差异（Ｐ＞０．０５）。结论：术前肿瘤内或肿瘤周围注入微粒子活性炭对口腔鳞癌颈淋巴清扫术有指导意义。
Objective: To investigate the guiding role of particulate activated carbon (CH40) in cervical lymph node dissection of oral squamous cell carcinoma. Methods: Twenty - two patients with oral squamous cell carcinoma were injected intraperitoneal or peri - tumorous suspension of granular activated carbon (CH40) preoperatively. According to the status of lymph node black staining during operation, the neck dissection was instructed. Results: Intraoperative findings of cervical lymph nodes with a wide range of different degrees of black dye, and even embedded in adipose tissue 1mm in diameter of lymph nodes; injection group black staining and non-black staining of lymph node metastasis rate was not significantly different; 42.5 lymph nodes were removed from each neck, which was significantly higher than that of the control group (P <0.01). There was no significant difference between the radical neck dissection and functional neck dissection (P> 0.05). CONCLUSION: Preoperative injection of fine particles of activated charcoal into the tumor or around the tumor is instructive for neck dissection of oral squamous cell carcinoma.