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本次研究应用果蝇 DNA 修复试验检测膳食纤维对诱变剂的吸附作用与提高用各种诱变剂处理的 DNA 修复缺陷的幼蝇存活率是否密切相关。实验结果表明,10种受试的纤维中,爱兰苔胶和木质素可明显减少3-氨基-1-甲基-5-氢-吡啶吲哚(Trp-P-2)对果蝇的致死性,而其余纤维如果胶、精氨酸和来自大豆的中性净化纤维均无作用。培养基中用 Trp-P-2和纤维处理的 DNA 修复缺陷雄幼蝇的死亡率与培养基中的游离 Trp-P-2的水平呈负相关。上述实验结果提示,膳食纤维可吸附 Trp-P-2,减少 Trp-
In this study, Drosophila DNA repair test was used to test whether the sorption of dietary fiber to mutagen was closely related to increasing the survival rate of young fly with DNA repair defects treated with various mutagens. The experimental results showed that, among the ten kinds of tested fibers, the alan gum and lignin significantly reduced the lethality of 3-amino-1-methyl-5-hydro-pyridineindole (Trp-P-2) While the remaining fibers, such as pectin, arginine and neutral purified fiber from soybean, have no effect. The mortality of the male-sterile male mice treated with Trp-P-2 and fiber-treated DNA in the medium was negatively correlated with the level of free Trp-P-2 in the medium. The above experimental results suggest that dietary fiber can adsorb Trp-P-2, reduce Trp-