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自1986年3月至1988年3月,对25例经病理证实的原发性肝细胞癌及5例转移性肝癌进行了经股动脉插管至肝动脉大剂量顺铂灌注,全身经静脉给硫代硫酸钠解毒的“双路化疗”,顺铂剂量,第一疗程为80～100mg/m~2,第二疗程为120～150mg/m~2加硫代硫酸钠解毒。治疗前后水化及甘露醇利尿。结果:经体检、B超、CT、肝血管造影复查,25例原发性肝癌中,12例肿块缩小25～50％或造影显示肿块供血主干变细,瘤体血管减少,部分血管闭塞,肿块缩小,肿瘤内出现坏死,呈低密度透亮区。5例转移性肝癌,4例出现上述改变,总有效率为53％(16/30)。毒性反应不严重,无严重肾毒性及白细胞减少。
From March 1986 to March 1988, 25 cases of pathologically confirmed primary hepatocellular carcinoma and 5 cases of metastatic liver cancer were infused through the femoral artery into the hepatic artery in large doses of cisplatin, intravenously throughout the body. Sodium thiosulfate detoxification “two-way chemotherapy,” Cisplatin dose, the first course of treatment is 80 ~ 100mg/m ~ 2, the second course of treatment is 120 ~ 150mg/m ~ 2 plus sodium thiosulfate detoxification. Hydration and mannitol diuresis before and after treatment. RESULTS: After physical examination, B-ultrasonography, CT, and hepatic angiography review, 25 cases of primary liver cancer, 12 cases were reduced 25 to 50% or angiography showed that the main blood supply of the tumor became thinner, the blood vessels of the tumor decreased, and some of the blood vessels occluded. Shrinking, necrosis occurs in the tumor, showing a low-density, translucent area. In 5 cases of metastatic liver cancer, the above changes occurred in 4 cases, and the total effective rate was 53% (16/30). The toxicity is not serious, no serious nephrotoxicity and leukopenia.