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目的观察亚甲蓝注射封闭术结合中草药外用熏洗治疗肛门瘙痒症的临床疗效。方法将50例肛门瘙痒症患者随机分为治疗组和对照组各25例。治疗组采用亚甲蓝注射封闭术结合中草药外用熏洗治疗,对照组采用亚甲蓝注射封闭术治疗,比较2组的近期和远期疗效。结果止痒疗效:第1、4周治疗组总有效率和显效率均高于对照组,但差异无统计学意义(P>0.05),第3个月时,治疗组疗效明显高于对照组,差异有统计学意义(P<0.05)。烧灼感发生率:第1周治疗组烧灼感患者比例明显少于对照组,差异有统计学意义(P<0.05)。再次注射发生率:治疗组再次注射患者的比例明显少于对照组,差异有统计学意义(P<0.05)。远期疗效:经随访,治疗组症状控制平稳率高于对照组,差异有统计学意义(P<0.05)。结论亚甲蓝注射封闭术结合中草药外用熏洗治疗肛门瘙痒症近期、远期疗效优于单纯使用亚甲蓝注射封闭法,而且还可明显减轻亚甲蓝注射后1周内的烧灼感。
Objective To observe the curative effect of methylene blue injection closure combined with topical fumigation of Chinese herbal medicine on pruritus of the anus. Methods 50 cases of pruritus were randomly divided into treatment group and control group of 25 cases. The treatment group was treated with methylene blue injection and topical fumigation of Chinese herbal medicine, while the control group was treated with methylene blue injection and closure. The short-term and long-term effects of the two groups were compared. The results of antipruritic effect: The first and the fourth week of treatment group total effective rate and markedly effective rate were higher than the control group, but the difference was not statistically significant (P> 0.05), the third month, the treatment group was significantly higher than the control group , The difference was statistically significant (P <0.05). Burning incidence: the first week of the treatment group, the proportion of patients with burning less significantly than the control group, the difference was statistically significant (P <0.05). Re-injection rate: the treatment group re-injection of patients was significantly less than the proportion of the control group, the difference was statistically significant (P <0.05). Long-term curative effect: After follow-up, the stable rate of symptom control in the treatment group was higher than that in the control group, with significant difference (P <0.05). Conclusion Methylene blue injection occlusion combined with topical fumigation of Chinese herbal medicine for the treatment of pruritus has short-term and long-term curative effects better than mere injection of methylene blue. It also significantly reduces the burning sensation within 1 week after injection of methylene blue.